021-51111890
购物车（0）
sales@molnova.cn
HOIPIN-8 sodium
CAS No. 2519537-70-1
HOIPIN-8 sodium ( —— )
产品货号. M35672 CAS No. 2519537-70-1
HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-α-mediated NF-κB activation compared to HOIPIN-1. HOIPIN-8 is a promising tool to explore cellular functions of LUBAC.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1512 | 有现货 |
|
| 5MG | ￥2334 | 有现货 |
|
| 10MG | ￥4005 | 有现货 |
|
| 25MG | ￥7452 | 有现货 |
|
| 50MG | ￥11652 | 有现货 |
|
| 100MG | ￥18054 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称HOIPIN-8 sodium
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-α-mediated NF-κB activation compared to HOIPIN-1. HOIPIN-8 is a promising tool to explore cellular functions of LUBAC.
-
产品描述HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-α-mediated NF-κB activation compared to HOIPIN-1. HOIPIN-8 is a promising tool to explore cellular functions of LUBAC.
-
体外实验——
-
体内实验——
-
同义词——
-
通路Immunology/Inflammation
-
靶点IκB kinase (IKK)
-
受体IκB/IKK
-
研究领域——
-
适应症——
化学信息
-
CAS Number2519537-70-1
-
分子量456.38
-
分子式C23H15F2N4NaO3
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESO=C(C1=CC=C(C2=CN(C)N=C2)C=C1/C=C/C(C3=C(C=C(C4=CNN=C4)C=C3F)F)=O)[O-].[Na+]
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
产品手册
关联产品
-
PHA-408
一种新型强效、高选择性、ATP 竞争性 IKK-2 抑制剂，IC50 为 40 nM。
-
MRT67307 HCl
MRT67307 是 TBK1、MARK1-4、IKKε 和 NUAK1 的激酶抑制剂（IC50 分别为：19、27-52、160 和 230 nM）。
-
Rosiglitazone HCl
Rosiglitazone (BRL 49653) hydrochloride 是一种具有口服活性的 PPARγ 选择性激动剂 (EC50: 60 nM, Kd: 40 nM)。Rosiglitazone hydrochloride 是一种 TRPC5 激活剂 (EC50: 30 μM) 和 TRPM3 抑制剂。Rosiglitazone hydrochloride 可用于肥胖、糖尿病、衰老、卵巢癌的研究。
